Analysis of clinical prognostic variables for Chronic Lymphocytic Leukemia decision-making problems
نویسندگان
چکیده
منابع مشابه
Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia.
BACKGROUND The clinical course of patients with chronic lymphocytic leukemia (CLL) is heterogeneous, with some patients experiencing rapid disease progression and others living for decades without requiring treatment. The Rai and Binet clinical staging systems are used to define disease extent and predict survival. The pathology laboratory also provides important prognostic information. METHO...
متن کاملMultivariate analysis of prognostic factors in chronic lymphocytic leukemia.
Prognostic factors in a group of 90 patients with chronic lymphocytic leukemia were studied by methods of survival analysis. The relationship between survival and a set of demographic, clinical and laboratory variables, and identification of subsets of variables that are associated with survival, was tested by multivariate analysis, which is based upon Cox proportional hazards regression models...
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BACKGROUND The clinical course of individual chronic lymphocytic leukemia (CLL) is highly variable and clinical staging systems do not help us to predict if and at what rate there will be disease progression in an individual patient diagnosed with early stage disease. Recently, several important observations related to other prognostic factors including lymphocyte doubling time (LDT), β2-microg...
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The Rai staging system is widely used and is easy to apply in clinical practice. The system introduced by Binet et al offers an advantage that it consists only of three stages and, therefore, is more practical for initiation of controlled therapeutic trials than the five-stage Rai system. However, when we take into consideration the survival curves, it is important to note that the Rai system h...
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Patients with chronic lymphocytic leukemia (CLL) can have variable courses, from indolent disease to rapid progression with limited response to treatment. The Rai and Binet staging systems were the first to classify patients into prognostic categories. Newer prognostic markers that correlate with shorter time to progression and time to treatment include elevated serum beta2M, TK, ZAP-70, and CD...
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ژورنال
عنوان ژورنال: Journal of Biomedical Informatics
سال: 2016
ISSN: 1532-0464
DOI: 10.1016/j.jbi.2016.02.017